| Saint Mary's Stadium | — | 5,500 seats | September 22, 1973 | — |
| Salt Palace | Salt Lake City | — | July 11, 1969 | basketball |
| Salt River Fields at Talking Stick | Scottsdale | 11,000 seats | February 11, 2011 | baseball |
| San Diego Stadium | San Diego | 70,561 seats | August 20, 1967 | rugby union, baseball, American football |
| SAP Center | San Jose | 19,190 seats | September 7, 1993 | ice hockey |
| Saputo Stadium | Mercier–Hochelaga-Maisonneuve | 19,619 seats | May 19, 2008 | association football |
| Sartain Hall | Alabama | 4,000 seats | 1962 | — |
| Schoenecker Arena | — | 1,800 seats | 2010 | — |
| Scotiabank Arena | Old Toronto | 19,800 seats | February 19, 1999 | basketball, ice hockey |
| Scotiabank Saddledome | Calgary | 16,605 seats | 1983 | badminton, ice hockey |
| Scott Stadium | Albemarle County | 61,500 seats | October 15, 1931 | American football |
| Scottsdale Stadium | Scottsdale | 12,000 seats | March 12, 1992 | — |
| ScottsMiracle-Gro Field | Columbus | 20,139 seats | July 3, 2021 | association football |
| SeatGeek Stadium | Bridgeview | 20,000 seats | June 11, 2006 | association football |
| Sharks Ice San Jose | — | — | 1994 | — |
| Sheboygan Municipal Auditorium and Armory | Wisconsin | — | — | — |
| Shell Energy Stadium | Houston | 22,039 seats | May 12, 2012 | association football, American football, rugby union |
| Simmons Bank Liberty Stadium | Memphis | 50,160 seats | September 16, 1965 | American football, association football |
| Sloan Park | Mesa | 15,000 seats | February 12, 2014 | baseball |
| Smisor Stadium | Kansas | 3,000 seats | — | American football |
| Smith Spectrum | — | 10,270 seats | December 1, 1970 | basketball |
| Snapdragon Stadium | San Diego | — | August 19, 2022 | association football, American football |
| SNHU Arena | Manchester | 9,852 seats | November 15, 2001 | ice hockey |
| SoFi Stadium | Inglewood | 70,240 seats | — | American football |
| Soldier Field | Chicago | 63,500 seats | October 9, 1924 | association football, American football |
| South End Grounds I | Massachusetts | 3,000 seats | May 16, 1871 | baseball |
| South End Grounds II | Massachusetts | 6,800 seats | May 25, 1888 | baseball |
| South End Grounds III | Massachusetts | 5,000 seats | July 20, 1894 | baseball |
| South Side Park | Chicago | 15,000 seats | 1890 | — |
| Sovereign Center | Reading | 9,000 seats | September 6, 2001 | — |
| Spokane Coliseum | Spokane | 5,400 seats | December 3, 1954 | — |
| Sporting Park | Kansas City | 25,000 seats | June 9, 2011 | association football |
| Sports Illustrated Stadium | Harrison | 25,189 seats | March 20, 2010 | association football |
| St. Louis Arena | St. Louis | 14,200 seats | September 23, 1929 | basketball |
| Staley Field | Illinois | — | — | American football |
| Stanford Stadium | Stanford | 50,424 seats | September 16, 2006 | association football, American football |
| State Farm Stadium | Glendale | 63,400 seats | August 1, 2006 | American football |
| Stevens Stadium | California | 11,500 seats | September 22, 1962 | baseball, American football, association football |
| Stevenson Field | Rhode Island | 3,500 seats | 1979 | association football, lacrosse |
| Stillman Stadium | Alabama | 9,000 seats | 1999 | — |
| Student Activity Complex | Texas | 8,500 seats | 2004 | — |
| Subaru Park | Chester | 18,500 seats | June 27, 2010 | association football |
| Surprise Stadium | Surprise | 10,714 seats | December 2002 | — |
| Sutter Health Park | West Sacramento | 11,093 seats | May 15, 2000 | baseball |